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Smokeless tobacco consumption, which is widespread throughout the world, leads to oral submucous fibrosis OSMFwhich is a long-lasting and devastating condition of the oral cavity with the potential for malignancy. In this review, we mainly focus on the consumption of smokeless tobacco, such as paan and gutkhaand the role of these substances in the induction of OSMF and ultimately oral cancer. The list of articles to be examined was established using citation discovery tools provided by PubMed, Scopus, and Google Scholar.

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Lee sits on a bar stool in a plexiglass box near a highway offramp in central Taiwan.

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Tobacco smokingis often refered to as "smoking", is the act of burning the dried leaves of the tobacco plant and inhaling the smoke. The practice was common to many Native American cultures and was introduced to the rest of the world by sailors following European exploration of the Americas. Tobacco smoke contains nicotinea stimulant which temporarily improves alertness and memory, but also forms a strong physical and psychological chemical dependence addiction. Medical research has determined that smoking is a major contributing factor towards many health problems, particularly lung canceremphysemaand cardiovascular disease.

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